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Opiranserin hydrochloride
CAS No. 1440796-75-7
Opiranserin hydrochloride( Opiranserin hydrochloride(1441000-45-8 Free base) )
Catalog No. M28926 CAS No. 1440796-75-7
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
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| 10MG | 417 | Get Quote |
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| 25MG | 689 | Get Quote |
|
| 50MG | 963 | Get Quote |
|
| 100MG | 1305 | Get Quote |
|
| 500MG | 2592 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameOpiranserin hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionOpiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
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DescriptionOpiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
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In Vitro——
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In Vivo——
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SynonymsOpiranserin hydrochloride(1441000-45-8 Free base)
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PathwayMembrane Transporter/Ion Channel
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TargetP2X Receptor
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RecptorDDR1
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Research Area——
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Indication——
Chemical Information
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CAS Number1440796-75-7
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Formula Weight430.97
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Molecular FormulaC21H35ClN2O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (116.02 mM)
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SMILESO=C(NCC1(N(C)C)CCOCC1)C2=CC(OC)=C(OCCCC)C(OC)=C2.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang Z, et al. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem. 2016 Jun 23;59(12):5911-6.
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